;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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While the OMIM database is open to the public, users seeking information about synndrome personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

Pathology of chemotaxis and random mobility. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility stndrome peripheral blood neutropenia with normal bone marrow granulocyte reserve.


Mobilization of leukocytes after exercise was defective. Expert curators review the literature and organize it to facilitate your work.

Both random mobility and chemotactic function were defective. A new disorder of neutrophil function. Skin window mobilization test and chemotaxis were normal.

Lazy leukocyte syndrome.

The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. Miller knew of 4 other cases.

We are determined to keep this website freely accessible. Clinical Synopsis Toggle Dropdown.

lazy leukocyte syndrome

None is familial and no parental consanguinity is known. Leukocyte phagocytosis and bactericidal activity were normal. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships.

A characteristic abnormality of actin distribution in neutrophils was demonstrated.

Lazy leukocyte syndrome.

Autosomal dominant new mutations. Please consider making a donation now and again in the future.

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Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. Single cases were reported by Costanopoulos et al. Transient ‘lazy-leukocyte’ syndrome during infancy.

A poor neutrophil response was obtained upon stimulation with both epinephrine and oazy, as well as upon induced inflammation by the Rebuck skin window technique.

A severe neutropenia was found. We need long-term secure funding to provide you the information that you need at your fingertips. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.